THE METABOLISM OF OROTIC ACID IN AEROBIC BACTERIA
نویسندگان
چکیده
منابع مشابه
The metabolism of orotic acid in aerobic bacteria.
cocci (Rogers, lW), Laetobaciuus cas& (Chattaway, lW), and Laclobaeiuus bulgcrricus, strain 09 (Wieland et d., 1950; Huff et d., 1950). Further studiea with L. bulgaricw, strain 09 have revealed that ureidosuccinic acid partially replacea that orotic acid ia also a nucleic acid pyrimidine a growth factor for one of the group C streptoprecursor in mammdim tissues. Studiea of orotic acid synthwia...
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Considerable knowledge concerning purine metabolism has been obtained from chemical and isotopic studies of urinary uric acid. Corresponding information in man is lacking for the closely related field of pyrimidine metabolism. The availability of ring-labeled orotic acid as a specific pyrimidine precursor (1), together with the presence of pseudouridine (5-ribosyluracil) and uracil, as specific...
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The urinary excretion of orotic acid, an intermediate in the pyrimidine biosynthetic pathway, is markedly increased in many inborn errors of the urea cycle and in a number of other disorders involving arginine metabolism. Carbamoyl phosphate, which accumulates within hepatic mitochondria in patients with ornithine transcarbamoylase deficiency, can diffuse to the cytosol and enter the pyrimidine...
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A survey on organisms able to use molecular hydrogen as electron donor in the energy-yielding process is presented. In the group of the aerobic hydrogen-oxidizing bacteria so far two types of hydrogenases have been encountered, a NAD-reducing, soluble enzyme (H2 : NAD oxidoreductase) and a membrane-bound enzyme unable to reduce pyridine nucleotides. With respect to the distribution of both type...
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Other studies in this laboratory (1) drew our attention to the possibility that erotic acid might be concerned with the maintenance of adequate lactation in the rat and with the survival of the young. Since no data were available on the erotic acid content of milk, this study was undertaken. The occurrence of erotic acid as a component of milk has been indicated since 1904, when Biscaro and Bel...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1955
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.69.3.250-255.1955